Endocrine Abstracts

Background: Thyroid dysgenesis (TD) represents a heterogeneous group of conditions and accounts for 85% of cases of congenital hypothyroidism (CH). This can be due to abnormal gland organogenesis which results in thyroid agenesis (35–40% of the cases), thyroid hypoplasia (5%) and thyroid ectopy (30–45%).Causes of CH can be classified into: one. dyshormonogenesis usually associated with goiter, caused by mutations in the genes coding for the pro...

Interferon use for the treatment of chronic hepatitis infection, is associated with the side effect of thyroid dysfunction. This is frequent and can be severe, particularly if not recognised. We performed a retrospective analysis of cases of interferon related thyroid dysfunction referred to our tertiary endocrinology centre. Fourteen cases were identified over the last 8 years. An analysis was carried out of demographic features, presentation, treatment and outcomes.<p cl...

We report the case of a 77-year-old lady who presented to hospital with confusion, agitation and polyuria. She had type 2 diabetes mellitus but was otherwise well with no history of weight loss, nephrolithiasis or fractures. There was no relevant family history. There were no abnormal findings on examination apart from dehydration and no focal neurological signs or lymphadenopathy. Investigations revealed a serum corrected calcium level of 4.71 nmol/l (normal 2.1–2.6). He...

Introduction: Advancement in modalities of treatment in childhood malignancies has improved the survival. Though Hypothyroidism is the first recognised and commonest thyroid disease in these set of patients, there is also an increased risk of subsequent primary thyroid cancer among the Survivors childhood malignancies who have had radiotherapy to the head, neck, or upper thorax. We hereby present case series of five patients who developed thyroid cancer after childhood cancer ...

Introduction: Covid -19 can cause serious or severe illness in anyone but those with chronic health conditions are at greater risk. Adrenal insufficiency (AI) is assumed to be associated with an increased Covid-19 infection risk, which could trigger an adrenal crisis. We conducted a retrospective study at district general hospital to assess the incidence of COVID-19 in Adrenal insufficiency patients.Method and material: Retrospective review of 43 patient...

A 48-year-old gentleman, father of 3 children, was referred to our endocrinology clinic, with sexual dysfunction and hypergonadotrophic hypogonadism. He had a history of severe Coronovirus-Disease-2019(COVID-19) pneumonitis for which he received prolonged ventilatory support. Post extubation, he experienced testicular pain and swelling. A testicular ultrasound showed a left-sided hydrocele, multiloculated epididymal-cyst and a right testicular cyst. He also described new sympt...

A 66 year old lady with a previous diagnosis of Retinitis Pigmentosa (RP) was referred to our endocrine clinic with excessive sweating and was also noted to have hypertension, thin skin, extensive bruising and central obesity. Her past medical history included a benign thyroid nodule, gastric erosions, osteoporosis, hyperlipidaemia and depression. On examination, blood pressure was 164/86 mmHg and BMI was 30.7 kg/m2 with central obesity. Biochemical testing revealed...

A 41 year old man was initially referred to lymphoedema clinic. He had leg swelling of 10 years duration but was otherwise fit and well. Examination revealed marked lipohypertrophy affecting his thighs bilaterally. There was no oedema and his distal lower limbs were normal. MRI investigation confirmed focal lipohypertrophy. Biochemical investigation revealed a very low albumin of <10 g/l, a low calcium of 1.96 mmol/l and hyperlipidaemia (cholesterol 9.3 mmol/l, LDL 6.4 mmo...

A 19-year-old gentleman, with Coffin-Siris-Syndrome(CSS)(ARID1B:c.6157dup gene-mutation), was referred to our endocrinology clinic, with rapid weight-gain and recent onset of Type-2-Diabetes. He was of short stature, he had central-adiposity, facial plethora, proximal myopathy and gynaecomastia. Endocrine testing revealed ACTH:61ng/l, Cortisol:772nmol/l, Total-Testosterone:2.8nmol/l, FSH:6.3U/l, LH:2.2U/l, Prolactin:87mU/l, IGF-1:61ug/l, TSH:0.18mU/l, T4:10.3 pmol/l, HbA1C:84m...